it pains sb to do sth

it pains sb to do sth formalused to say that it is very difficult and upsetting for someone to have to do something（不得不）做某事令某人难受

• set one's heart（或hopes）on
• magnetocardiograms
• psoroptic mange
• cumec
• rostellate
• have something up your sleeve
• as regards sb/sth
• suburbanising
• Cobbs' disease
• succinctorium
• Absaroka
• apartotel
• chaits
• diplomatic privileges
• squeak by
• adsorptions
• mesenchymal
• nolo contenderes
• glass harp
• porkets
• you're a fine one to talk
• artsier
• ridiculously
• Nitrite Reductases
• globular star cluster
• bacillary
• powdery mildew of mulberry
• peel tires
• Elassomatidae
• in a pig's eye
• fibrocystic (breast) disease
• ferrum
• open out
• hum bars
• classist
• self-consciousnesses
• biome
• Barrovian metamorphic zone
• Alonso, Alonzo
• bingy
• sciuroid
• open die
• be soaked to the skin
• microfissure
• automated radar plotting aid
• maliciously
• pan in
• mess together
• ayahuasca
• mortgage bonds
• ballistic measurement
• coarse setting
• intaglio
• electret headphone
• furrow wall
• polychaete
• vaccinizations
• manicured
• Arbitration Court
• in-pile
• chronometric radiosonde
• bench points
• service breaks
• open a door to
• orchard bush
• goblin
• canned
• Chordariaceae
• stakeholdings
• ringdoves
• myrtaless
• fountainhead
• distemperatures
• foreclosable
• game play
• transvestists
• haulageway
• antiarins
• Schultz, Charles Monroe
• adopted daughter
• eagre
• chickfurter
• nilgau
• crimpiest
• happy camper
• hamantashen
• bluish
• mum's the word.
• thrones
• put (或set) someone's heart at rest
• paramilitary operation
• combustible
• reproachest
• jollier
• amperes
• big deal
• superparasite
• a number of
• multivariable
• quasher